1491917-83-9

1491917-83-9 structure

Name: Sacituzumab govitecan
Chemical Name: Sacituzumab govitecan
CAS Number: 1491917-83-9
Molecular Formula: C₇₆H₁₀₄N₁₂O₂₄S
Molecular Weight: 1601.77000
Catalog: Research Areas Cancer
Create Date: 2021-10-03 10:26:23
Modify Date: 2024-01-17 17:59:54
Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].

Name	Sacituzumab govitecan
Synonyms	hRS7-SN38 IMMU-132 IMMU 132 N-[4-(-Carboxycyclohexylmethyl)]maleimide

Description	Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer
In Vivo	Sacituzumab govitecan (IMMU-132) (17.5 mg/kg; twice weekly for 4 weeks) results in significant anti-tumor effects in mice bearing human gastric cancer xenografts[1].
References	[1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31.