1216420-11-9

1216420-11-9 structure

Name: Desmethyl Erlotinib-d4
Chemical Name: Desmethyl Erlotinib-d4
CAS Number: 1216420-11-9
Molecular Formula: C₂₁H₁₇D₄N₃O₄
Molecular Weight: 383.43
Catalog: Research Areas Cancer
Create Date: 2021-10-07 11:18:27
Modify Date: 2024-01-10 15:49:43
Desmethyl Erlotinib-d4 (OSI-420-d4 free base) is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2].

Name	Desmethyl Erlotinib-d4

Description	Desmethyl Erlotinib-d4 (OSI-420-d4 free base) is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2].
Related Catalog	Research Areas >> Cancer
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Thappali SR, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.Sci Pharm. 2012 Jul-Sep;80(3):633-46.

Molecular Formula	C₂₁H₁₇D₄N₃O₄
Molecular Weight	383.43