1802909-49-4
1802909-49-4 structure
- Name: INCB059872
- Chemical Name: INCB059872
- CAS Number: 1802909-49-4
- Molecular Formula: C23H34N2O3
- Molecular Weight: 386.53
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2021-10-18 18:54:24
- Modify Date: 2024-01-09 08:13:52
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INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 can be used for the research of myeloid leukemia[1].
| Name | INCB059872 |
|---|
| Description | INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 can be used for the research of myeloid leukemia[1]. |
|---|---|
| Related Catalog | |
| Target |
LSD1[1] |
| In Vitro | INCB059872 (25 nM; 48 hours; 293T cells) increases enhancer activity and gene expression[1]. INCB059872 (25 nM; 24 hours; THP-1 cells) makes THP-1 show a growth defect within one cell doubling time or approximately 3 days. INCB059872 (100 nM; 24 hours; MV-4–11 cells) treated MV-4–11 cells continues to grow as DMSO-treated cells for multiple cell divisions. INCB059872 (THP-1 cells) regulates PRO-seq analysis identifies genes and enhancers[1]. Western Blot Analysis[1] Cell Line: 293T cells Concentration: 250 nM Incubation Time: 48 hours Result: Increased enhancer activity and gene expression. |
| In Vivo | INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days) makes single-cell RNA-seq revealing changes in bone marrow progenitor populations[1]. Animal Model: Mice[1] Dosage: 10 mg/kg Administration: P.o.; 0, 4, or 6 days Result: Single-cell RNA-seq revealed changes in bone marrow progenitor populations. |
| References |
| Molecular Formula | C23H34N2O3 |
|---|---|
| Molecular Weight | 386.53 |