DC Chemicals Limited
China
Product Name: MM 419447
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Taiwan Oyi peptide Co. Ltd
China
Product Name: MM 419447
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

1092457-78-7

1092457-78-7 structure

1092457-78-7 structure

Name: MM 419447
Chemical Name: MM 419447
CAS Number: 1092457-78-7
Molecular Formula: C₅₀H₇₀N₁₄O₁₉S₆
Molecular Weight: 1363.56
Catalog: Signaling Pathways GPCR/G Protein Guanylate Cyclase
Create Date: 2021-10-07 09:17:59
Modify Date: 2024-01-07 13:00:07
MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].

Name	MM 419447

Description	MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase
In Vitro	MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].
In Vivo	MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1] Animal Model: Female Sprague-Dawley rats[1] Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The Cmax, AUC0-6 and Tmax were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.
References	[1]. Busby RW, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther. 2013;344(1):196-206.

Molecular Formula	C₅₀H₇₀N₁₄O₁₉S₆
Molecular Weight	1363.56