1092457-78-7
1092457-78-7 structure
- Name: MM 419447
- Chemical Name: MM 419447
- CAS Number: 1092457-78-7
- Molecular Formula: C50H70N14O19S6
- Molecular Weight: 1363.56
- Catalog: Signaling Pathways GPCR/G Protein Guanylate Cyclase
- Create Date: 2021-10-07 09:17:59
- Modify Date: 2024-01-07 13:00:07
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MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].
| Name | MM 419447 |
|---|
| Description | MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1]. |
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| Related Catalog | |
| In Vitro | MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1]. |
| In Vivo | MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1] Animal Model: Female Sprague-Dawley rats[1] Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The Cmax, AUC0-6 and Tmax were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively. |
| References |
| Molecular Formula | C50H70N14O19S6 |
|---|---|
| Molecular Weight | 1363.56 |