Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PCSK9 degrader 1
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: PCSK9 degrader 1
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g ￥220.0/10ml
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2215931-60-3

2215931-60-3 structure

2215931-60-3 structure

Name: PCSK9 degrader 1
Chemical Name: PCSK9 degrader 1
CAS Number: 2215931-60-3
Molecular Formula: C₃₄H₃₄FN₃O₆S
Molecular Weight: 631.71
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2021-10-07 19:47:50
Modify Date: 2025-08-25 07:52:13
PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function[1].

Name	PCSK9 degrader 1

Description	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
In Vitro	Biphenyl acid PCSK9 degrader 1 (compound 9) binds to and thermally stabilizes PCSK9 in a complex environment such as Huh7 lysate[1]. PCSK9 degrader 1 (compound 9), with high affinity for recombinant PCSK9 and target engagement in cell lysate, could be used as a recruiting element to promote the selective degradation of PCSK9[1].
References	[1]. Whitney L Petrilli, et al. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol. 2020 Jan 16;27(1):32-40.e3.

Molecular Formula	C₃₄H₃₄FN₃O₆S
Molecular Weight	631.71

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