1821038-80-5
1821038-80-5 structure
- Name: PI3Kγ inhibitor 4
- Chemical Name: PI3Kγ inhibitor 4
- CAS Number: 1821038-80-5
- Molecular Formula: C20H24N4O4S
- Molecular Weight: 416.49
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2021-10-07 20:02:25
- Modify Date: 2024-01-16 07:44:51
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PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation[1].
| Name | PI3Kγ inhibitor 4 |
|---|
| Description | PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation[1]. |
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| Related Catalog | |
| Target |
PI3Kγ:40 nM (IC50) PI3Kα:300 nM (IC50) |
| In Vitro | PI3Kγ inhibitor 4 inhibits PI3Kγ and PI3Kα in U937 cells, with IC50s of 120 nM and 6250 nM, respectively[1]. |
| In Vivo | PI3Kγ inhibitor 4 (10-20 mg/kg; a single p.o.) dose dependently inhibits the amplitude of the enhanced pause (ΔPenh) response to ovalbumin in a model of airway inflammation[1]. PI3Kγ inhibitor 4 (a single p.o.) exhibits high oral bioavailability (72, 94 and 122%) and Cmax (1.53, 12.2 and 25.2 μM) following oral administration (10, 100 and 300 mg/kg) in rats[1]. |
| References |
| Molecular Formula | C20H24N4O4S |
|---|---|
| Molecular Weight | 416.49 |