1330238-38-4

1330238-38-4 structure

Name: Quetiapine Sulfoxide-d8
Chemical Name: Quetiapine Sulfoxide-d8
CAS Number: 1330238-38-4
Molecular Formula: C₂₁H₁₇D₈N₃O₃S
Molecular Weight: 407.56
Catalog: Research Areas Neurological Disease
Create Date: 2021-10-19 19:18:12
Modify Date: 2024-01-09 18:23:53
Quetiapine Sulfoxide-d8 (Quetiapine S-oxide-d8) is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].

Name	Quetiapine Sulfoxide-d8

Description	Quetiapine Sulfoxide-d8 (Quetiapine S-oxide-d8) is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. [3]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.

Molecular Formula	C₂₁H₁₇D₈N₃O₃S
Molecular Weight	407.56