Quetiapine Sulfoxide-d8

Modify Date: 2024-01-09 18:23:53

Quetiapine Sulfoxide-d8 Structure
Quetiapine Sulfoxide-d8 structure
Common Name Quetiapine Sulfoxide-d8
CAS Number 1330238-38-4 Molecular Weight 407.56
Density N/A Boiling Point N/A
Molecular Formula C21H17D8N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Quetiapine Sulfoxide-d8


Quetiapine Sulfoxide-d8 (Quetiapine S-oxide-d8) is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].

 Names

Name Quetiapine Sulfoxide-d8

 Quetiapine Sulfoxide-d8 Biological Activity

Description Quetiapine Sulfoxide-d8 (Quetiapine S-oxide-d8) is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537.

[3]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.

 Chemical & Physical Properties

Molecular Formula C21H17D8N3O3S
Molecular Weight 407.56
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