Shanghai Nianxing Industrial Co., Ltd
China
Product Name: sulfo-DGN462 sodium
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

1401203-09-5

1401203-09-5 structure

1401203-09-5 structure

Name: sulfo-DGN462 sodium
Chemical Name: sulfo-DGN462 sodium
CAS Number: 1401203-09-5
Molecular Formula: C₅₃H₆₀N₅NaO₁₂S₂
Molecular Weight: 1046.19
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2021-10-23 08:09:46
Modify Date: 2025-08-23 18:42:21
sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].

Name	sulfo-DGN462 sodium

Description	sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vitro	DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].
References	[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639.

Molecular Formula	C₅₃H₆₀N₅NaO₁₂S₂
Molecular Weight	1046.19

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.