126695-58-7
- Name: 4-Azido-2,3,5,6-tetrafluorobenzoicacid
- Chemical Name: N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate
- CAS Number: 126695-58-7
- Molecular Formula: C11H4F4N4O4
- Molecular Weight: 332.16700
- Catalog: Organic raw materials Organic fluorine compound Fluorobenzoic acid series
- Create Date: 2018-12-13 19:02:43
- Modify Date: 2024-01-09 18:06:47
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4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate |
|---|---|
| Synonyms |
4-Azido-2,3,5,6-tetrafluorobenzoic Acid N-Succinimidyl Ester
(2,5-dioxopyrrolidin-1-yl) 4-azido-2,3,5,6-tetrafluorobenzoate ATFB,SE [4-Azido-2,3,5,6-tetrafluorobenzoic acid,succinimidyl ester] |
| Description | 4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Noncleavable |
| Melting Point | 104-105ºC |
|---|---|
| Molecular Formula | C11H4F4N4O4 |
| Molecular Weight | 332.16700 |
| Exact Mass | 332.01700 |
| PSA | 113.43000 |
| LogP | 1.79626 |
| Storage condition | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
| Stability | Light and Moisture Sensitive. Store in freezer |
| Hazard Codes | F+ |
|---|---|
| RIDADR | UN 1325 4.1/PG III |
| Packaging Group | III |
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| Literature: Journal of Organic Chemistry, , vol. 55, # 11 p. 3640 - 3647 |
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| Literature: Journal of Organic Chemistry, , vol. 55, # 11 p. 3640 - 3647 |
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| Literature: Journal of Physical Chemistry, , vol. 98, # 2 p. 412 - 419 |
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| Literature: Marcinek, Andrzej; Platz, Matthew S.; Chan, Stephen Y.; Floresca, Rey; Rajagopalan, Krishnan; et al. Journal of Physical Chemistry, 1994 , vol. 98, # 2 p. 412 - 419 |
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| Literature: THE STATE OF OREGON ACTING BY AND THROUGH STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND Patent: US2010/28559 A1, 2010 ; |
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| Literature: Journal of Physical Chemistry, , vol. 98, # 2 p. 412 - 419 |
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| Literature: Journal of Organic Chemistry, , vol. 55, # 11 p. 3640 - 3647 |
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| Literature: Journal of Organic Chemistry, , vol. 55, # 11 p. 3640 - 3647 |
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| Literature: Journal of Organic Chemistry, , vol. 55, # 11 p. 3640 - 3647 |
| Precursor 9 | |
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| DownStream 1 | |
