1216805-11-6

1216805-11-6 structure

Name: Thalidomide-5-COOH
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid
CAS Number: 1216805-11-6
Molecular Formula: C₁₄H₁₀N₂O₆
Molecular Weight: 302.24
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-12-19 20:38:32
Modify Date: 2024-01-03 22:52:30
Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid
Synonyms	1H-Isoindole-5-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo- 2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid MFCD32063447

Description	Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.