1216805-11-6
1216805-11-6 structure
- Name: Thalidomide-5-COOH
- Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid
- CAS Number: 1216805-11-6
- Molecular Formula: C14H10N2O6
- Molecular Weight: 302.24
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2021-12-19 20:38:32
- Modify Date: 2025-08-25 19:21:57
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Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].
| Name | 2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid |
|---|---|
| Synonyms |
1H-Isoindole-5-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-
2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid MFCD32063447 |
| Description | Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.3±50.0 °C at 760 mmHg |
| Molecular Formula | C14H10N2O6 |
| Molecular Weight | 302.24 |
| Flash Point | 345.9±30.1 °C |
| Exact Mass | 302.053894 |
| LogP | 0.22 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.676 |
| Storage condition | 2-8℃ |