Thalidomide-5-COOH
Modify Date: 2025-08-25 19:21:57
Thalidomide-5-COOH structure
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Common Name | Thalidomide-5-COOH | ||
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| CAS Number | 1216805-11-6 | Molecular Weight | 302.24 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 648.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H10N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 345.9±30.1 °C | |
Use of Thalidomide-5-COOHThalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1]. |
| Name | 2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1]. |
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| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.3±50.0 °C at 760 mmHg |
| Molecular Formula | C14H10N2O6 |
| Molecular Weight | 302.24 |
| Flash Point | 345.9±30.1 °C |
| Exact Mass | 302.053894 |
| LogP | 0.22 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.676 |
| Storage condition | 2-8℃ |
| 1H-Isoindole-5-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo- |
| 2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid |
| MFCD32063447 |