1227638-29-0

1227638-29-0 structure

Name: Pirepemat
Chemical Name: Irl-752
CAS Number: 1227638-29-0
Molecular Formula: C₁₁H₁₃F₂NO
Molecular Weight: 213.22
Catalog: Research Areas Neurological Disease
Create Date: 2022-01-18 19:44:46
Modify Date: 2024-01-14 16:18:16
Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease[1][2].

Name	Irl-752
Synonyms	3-(2,3-Difluorophenyl)-3-methoxypyrrolidine Irl-752 Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-

Description	Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	IRL752 displayed its highest in vitro affinities for 5-HT and NA-related targets[2].
In Vivo	IRL752 (3.7-100 µmol/kg, s.c.) has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reversed deficits resulting from hypomonoaminergic function[2]. Animal Model: Normal rats[2]. Dosage: 3.7-100 µmol/kg. Administration: s.c., 30 min prior to testing. Result: Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.
References	[1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease. [2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.