1373887-29-6

1373887-29-6 structure

Name: ER176
Chemical Name: ER-176
CAS Number: 1373887-29-6
Molecular Formula: C₂₀H₂₀ClN₃O
Molecular Weight: 353.85
Catalog: Research Areas Neurological Disease
Create Date: 2021-12-23 17:01:04
Modify Date: 2024-01-03 18:49:30
ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].

Name	ER-176
Synonyms	ER-176 N-[(2R)-2-Butanyl]-4-(2-chlorophenyl)-N-methyl-2-quinazolinecarboxamide 1CFA2S833A 2-Quinazolinecarboxamide, 4-(2-chlorophenyl)-N-methyl-N-[(1R)-1-methylpropyl]-

Description	ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	ER176 shows homozygous high-affinity binders (HABs)/heterozygous mixed affinity binders (MABs) ratio for BP ND (specific-to-non-displaceable ratio of distribution volumes) of 1.2[1].
References	[1]. Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMMI Res. 2017 Oct 16;7(1):84. [2]. Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954.