ER176

Modify Date: 2024-01-03 18:49:30

ER176 Structure
ER176 structure
Common Name ER176
CAS Number 1373887-29-6 Molecular Weight 353.85
Density 1.2±0.1 g/cm3 Boiling Point 481.8±37.0 °C at 760 mmHg
Molecular Formula C20H20ClN3O Melting Point N/A
MSDS N/A Flash Point 245.2±26.5 °C

 Use of ER176


ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].

 Names

Name ER-176
Synonym More Synonyms

 ER176 Biological Activity

Description ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].
Related Catalog
In Vitro ER176 shows homozygous high-affinity binders (HABs)/heterozygous mixed affinity binders (MABs) ratio for BP ND (specific-to-non-displaceable ratio of distribution volumes) of 1.2[1].
References

[1]. Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMMI Res. 2017 Oct 16;7(1):84.

[2]. Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 481.8±37.0 °C at 760 mmHg
Molecular Formula C20H20ClN3O
Molecular Weight 353.85
Flash Point 245.2±26.5 °C
Exact Mass 353.129486
LogP 4.19
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.615

 Synonyms

ER-176
N-[(2R)-2-Butanyl]-4-(2-chlorophenyl)-N-methyl-2-quinazolinecarboxamide
1CFA2S833A
2-Quinazolinecarboxamide, 4-(2-chlorophenyl)-N-methyl-N-[(1R)-1-methylpropyl]-