1403894-72-3
1403894-72-3 structure
- Name: Mesdopetam
- Chemical Name: N-{2-[3-Fluoro-5-(methylsulfonyl)phenoxy]ethyl}-1-propanamine
- CAS Number: 1403894-72-3
- Molecular Formula: C12H18FNO3S
- Molecular Weight: 275.34
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2021-12-20 17:32:48
- Modify Date: 2025-08-28 08:24:19
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Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].
| Name | N-{2-[3-Fluoro-5-(methylsulfonyl)phenoxy]ethyl}-1-propanamine |
|---|---|
| Synonyms |
1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-
N-{2-[3-Fluoro-5-(methylsulfonyl)phenoxy]ethyl}-1-propanamine |
| Description | Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
D3 Receptor |
| In Vivo | Mesdopetam (IRL790) (3.7, 11, 33, or 100 µmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1]. Mesdopetam (10 mg/kg; intraperitoneally; fourteen-week-old male C57BL/J mice) promotes a sedative effect similar to haloperidol with significantly reduced total distance traveled and reduced average speed[2]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3.7, 11, 33, or 100 µmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl) Administration: s.c. was administered subcutaneously 4 min before the start of recording Result: Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 428.5±45.0 °C at 760 mmHg |
| Molecular Formula | C12H18FNO3S |
| Molecular Weight | 275.34 |
| Flash Point | 212.9±28.7 °C |
| Exact Mass | 275.099152 |
| LogP | 1.50 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.500 |