1547162-46-8

1547162-46-8 structure

Name: CC-17369
Chemical Name: CC-17369
CAS Number: 1547162-46-8
Molecular Formula: C₁₃H₁₁N₃O₅
Molecular Weight: 289.24
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2022-01-14 20:09:20
Modify Date: 2024-01-16 10:21:51
CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].

Name	CC-17369
Synonyms	1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-7-hydroxy- CC-17369 4-Amino-2-(2,6-dioxo-3-piperidinyl)-7-hydroxy-1H-isoindole-1,3(2H)-dione 2Z346T86O9 UNII:2Z346T86O9

Description	CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
References	[1]. Hoffmann M, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013;71(2):489-501. [2]. Makbul C, et al. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14.

Hazard Codes	Xi