2414373-42-3

2414373-42-3 structure

Name: RET-IN-21
Chemical Name: 4-{5-[(4-Pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl}benzamide
CAS Number: 2414373-42-3
Molecular Formula: C₁₉H₁₆N₆O
Molecular Weight: 344.370
Catalog: Research Areas Cancer
Create Date: 2022-04-07 16:29:40
Modify Date: 2024-04-03 17:45:27
RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].

Name	4-{5-[(4-Pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl}benzamide
Synonyms	Benzamide, 4-[5-[(4-pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]- 4-{5-[(4-Pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl}benzamide

Description	RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med. Chem. Lett. 2020, 11, 4, 497–505