RET-IN-21

Modify Date: 2024-04-03 17:45:27

RET-IN-21 Structure
RET-IN-21 structure
Common Name RET-IN-21
CAS Number 2414373-42-3 Molecular Weight 344.370
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C19H16N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RET-IN-21


RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].

 Names

Name 4-{5-[(4-Pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl}benzamide
Synonym More Synonyms

 RET-IN-21 Biological Activity

Description RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].
Related Catalog
References

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med. Chem. Lett. 2020, 11, 4, 497–505

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C19H16N6O
Molecular Weight 344.370
Exact Mass 344.138550
LogP -0.72
Index of Refraction 1.729

 Synonyms

Benzamide, 4-[5-[(4-pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]-
4-{5-[(4-Pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl}benzamide
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