2364554-48-1
2364554-48-1 structure
- Name: Aficamten
- Chemical Name: Aficamten
- CAS Number: 2364554-48-1
- Molecular Formula: C18H19N5O2
- Molecular Weight: 337.38
- Catalog: Signaling Pathways Cytoskeleton Myosin
- Create Date: 2021-12-19 22:13:01
- Modify Date: 2024-01-02 15:27:09
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Aficamten (CK-274) is a novel cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM)[1].
| Name | Aficamten |
|---|---|
| Synonyms | CK-274 |
| Description | Aficamten (CK-274) is a novel cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM)[1]. |
|---|---|
| Related Catalog | |
| In Vivo | "Aficamten is a next-generation cardiac myosin inhibitor that provides a projected human half-life appropriate for once a day dosing, reaching steady state within two weeks, and demonstrates a wide therapeutic window in vivo with a clear PK/PD relationship[1]. Aficamten exhibits moderate oral bioavailability (mouse 98%, rat 55%, rat 58%,rat 79%, dog 45%, monkey 41%) following oral administration (mouse 1 mg/kg, rat 2 mg/kg, rat 3 mg/kg, rat 8 mg/kg, dog 1 mg/kg and monkey 1 mg/kg)[1]. Aficamten exhibits terminal elimination half-lives (mouse 4.5 h, rat 3.0 h, dog 33.8 h and, monkey 8.1 h) following intravenous administration (mouse 0.5 mg/kg, rat 1 mg/kg, dog 1 mg/kg and monkey 1.0 mg/kg)[1]." |
| References |
| Molecular Formula | C18H19N5O2 |
|---|---|
| Molecular Weight | 337.38 |