1452459-50-5

1452459-50-5 structure

Name: FPI-1523
Chemical Name: FPI-1523
CAS Number: 1452459-50-5
Molecular Formula: C₉H₁₄N₄O₇S
Molecular Weight: 322.30
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-01-14 11:39:50
Modify Date: 2024-01-10 09:13:02
FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1].

Name	FPI-1523

Description	FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	β-lactamase[1]
In Vitro	FPI-1523 inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1]. FPI-1523 inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].
References	[1]. King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8.

Molecular Formula	C₉H₁₄N₄O₇S
Molecular Weight	322.30