2484739-48-0

2484739-48-0 structure

Name: PROTAC CBP/P300 Degrader-1
Chemical Name: PROTAC CBP/P300 Degrader-1
CAS Number: 2484739-48-0
Molecular Formula: C₄₆H₅₃F₂N₁₁O₆
Molecular Weight: 893.98
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-01-05 16:37:21
Modify Date: 2024-01-18 12:56:24
PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines[1].

Name	PROTAC CBP/P300 Degrader-1

Description	PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Cereblon
In Vitro	PROTAC CBP/P300 Degrader-1 shows LNCaP prostate cancer cell viability inhibition (IC50=0.4 nM). PROTAC CBP/P300 Degrader-1 (10 nM) induces degradation of P300 (≥ 80%)[1]. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancel cell lines (IC50s ranging from 0.1-141.4 nM for HEL, NOMO-1, MOLM-13, HL-60, MEG-01, MM.IS, MM.1R, NCL-H929, RPM-8226, AMO-1, WSU-DLCL2, Karpas-422, Pfeiffer, SU-DHL-1, LNCap clone FGC, VCap; 22RV1, NCI-H520, NCI-H703, LK-2, MCE-7, and SK-BR-3 cells)[1].
References	[1]. Jing Liu, et al. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use. WO2020173440A1.