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2170507-65-8

2170507-65-8 structure
2170507-65-8 structure
  • Name: Tadnersen
  • Chemical Name: Tadnersen
  • CAS Number: 2170507-65-8
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2022-01-23 09:15:49
  • Modify Date: 2024-01-10 12:40:11
  • Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion[1].

Name Tadnersen
Description Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion[1].
Related Catalog
In Vitro Tadnersen (BIIB078) is an RNAse H oligomer that selectively inhibits mutant C9ORF72 transcripts. Tadnersen is used for the research of Amyotrophic Lateral Sclerosis (ALS)[2].
References

[1]. Smeyers J, et al. C9ORF72: What It Is, What It Does, and Why It Matters. Front Cell Neurosci. 2021;15:661447. Published 2021 May 5.

[2]. Aoki Y, et al. Emerging Oligonucleotide Therapeutics for Rare Neuromuscular Diseases [published online ahead of print, 2021 Jun 3]. J Neuromuscul Dis. 2021;10.3233/JND-200560.

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