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40313-92-6

40313-92-6 structure
40313-92-6 structure
  • Name: Thalidomide-5-methyl
  • Chemical Name: Thalidomide-5-methyl
  • CAS Number: 40313-92-6
  • Molecular Formula: C14H12N2O4
  • Molecular Weight: 272.26
  • Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
  • Create Date: 2021-12-20 00:13:32
  • Modify Date: 2024-01-03 11:06:15
  • Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].
Name Thalidomide-5-methyl
Description Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A.
Molecular Formula C14H12N2O4
Molecular Weight 272.26

Chemsrc provides CAS#:40313-92-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 40313-92-6 | Chemsrc address: https://m.chemsrc.com/en/baike/1687379.html

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