2599846-44-1

2599846-44-1 structure

Name: Thalidomide-Piperazine-Piperidine hydrochloride
Chemical Name: Thalidomide-Piperazine-Piperidine hydrochloride
CAS Number: 2599846-44-1
Molecular Formula: C₂₂H₂₈ClN₅O₄
Molecular Weight: 461.94
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2022-05-31 08:06:44
Modify Date: 2025-08-27 09:17:59
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-Piperazine-Piperidine hydrochloride

Description	Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

Molecular Formula	C₂₂H₂₈ClN₅O₄
Molecular Weight	461.94

Hazard Codes	Xi