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1359415-02-3

1359415-02-3 structure
1359415-02-3 structure
  • Name: UBE2T/FANCL-IN-1
  • Chemical Name: UBE2T/FANCL-IN-1
  • CAS Number: 1359415-02-3
  • Molecular Formula: C19H31N7
  • Molecular Weight: 357.50
  • Catalog: Research Areas Cancer
  • Create Date: 2022-01-05 19:00:57
  • Modify Date: 2024-01-11 19:20:02
  • UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].
Name UBE2T/FANCL-IN-1
Description UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].
Related Catalog
In Vitro UBE2T/FANCL-IN-1 (CU2) completely inhibits the ubiquitylation of GST-FANCLRING at 100 μM. UBE2T/FANCL-IN-1 (500 μM) reduced the level of mUb-FANCD2 in response to HU treatment. UBE2T/FANCL-IN-1 (500 μM) also reducesthe level of mUb-FANCD2 generated in response to Cisplatin (10 μM) treatment for 6, 12, and 24 hours. The combination of 250 μM UBE2T/FANCL-IN-1 with 15 μM carboplatin led to an even more pronounced decrease in cell proliferation/growth, with the cells being <50% confluent after 8 days[1].
References

[1]. Cornwell MJ, et al. Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway. ACS Chem Biol. 2019;14(10):2148-2154.
Molecular Formula C19H31N7
Molecular Weight 357.50

Chemsrc provides CAS#:1359415-02-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 1359415-02-3 | Chemsrc address: https://m.chemsrc.com/en/baike/1687398.html

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