UBE2T/FANCL-IN-1
Modify Date: 2024-01-11 19:20:02
UBE2T/FANCL-IN-1 structure
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Common Name | UBE2T/FANCL-IN-1 | ||
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| CAS Number | 1359415-02-3 | Molecular Weight | 357.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H31N7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UBE2T/FANCL-IN-1UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1]. |
| Name | UBE2T/FANCL-IN-1 |
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| Description | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1]. |
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| Related Catalog | |
| In Vitro | UBE2T/FANCL-IN-1 (CU2) completely inhibits the ubiquitylation of GST-FANCLRING at 100 μM. UBE2T/FANCL-IN-1 (500 μM) reduced the level of mUb-FANCD2 in response to HU treatment. UBE2T/FANCL-IN-1 (500 μM) also reducesthe level of mUb-FANCD2 generated in response to Cisplatin (10 μM) treatment for 6, 12, and 24 hours. The combination of 250 μM UBE2T/FANCL-IN-1 with 15 μM carboplatin led to an even more pronounced decrease in cell proliferation/growth, with the cells being <50% confluent after 8 days[1]. |
| References |
| Molecular Formula | C19H31N7 |
|---|---|
| Molecular Weight | 357.50 |