2561494-77-5
2561494-77-5 structure
- Name: UNC6934
- Chemical Name: UNC6934
- CAS Number: 2561494-77-5
- Molecular Formula: C24H21N5O4
- Molecular Weight: 443.16
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2022-03-18 11:09:27
- Modify Date: 2025-08-24 10:43:45
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UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays.
| Name | UNC6934 |
|---|
| Description | UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays. |
|---|
| Molecular Formula | C24H21N5O4 |
|---|---|
| Molecular Weight | 443.16 |