916574-83-9
916574-83-9 structure
- Name: CEP-9722
- Chemical Name: CEP-9722
- CAS Number: 916574-83-9
- Molecular Formula: C24H26N4O3
- Molecular Weight: 418.49
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2022-01-08 21:46:59
- Modify Date: 2024-01-10 16:16:40
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CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2].
| Name | CEP-9722 |
|---|
| Description | CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PARP-1:20 nM (IC50) PARP-2:6 nM (IC50) |
| In Vivo | CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; for 5 days a week for 4 weeks) shows dose-dependent antitumor activity in RT4 xenografts; 200 mg/kg daily is better than control and 100 mg/kg is not[1]. Animal Model: Nude mice bearing subcutaneous RT4 human urothelial carcinoma (UC) tumors[1] Dosage: 100 or 200 mg/kg/day Administration: Oral gavage; once daily; for 5 days a week for 4 weeks Result: Showed dose-dependent antitumor activity in RT4 xenografts. |
| References |
| Molecular Formula | C24H26N4O3 |
|---|---|
| Molecular Weight | 418.49 |