2044953-70-8
2044953-70-8 structure
- Name: Seclidemstat mesylate
- Chemical Name: Seclidemstat mesylate
- CAS Number: 2044953-70-8
- Molecular Formula: C21H27ClN4O7S2
- Molecular Weight: 547.04
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2022-01-09 13:02:33
- Modify Date: 2024-01-12 08:53:07
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Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma[1][2].
| Name | Seclidemstat mesylate |
|---|
| Description | Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma[1][2]. |
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| Related Catalog | |
| Target |
Ki: 31 nM (LSD1)[1] IC50: 13 nM (LSD1)[1] |
| In Vitro | Seclidemstat (72 hours) mesylate inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells)[2]. Seclidemstat (72 hours) mesylate promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434 cells)[2]. Seclidemstat (3 μM) mesylate promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line[2]. |
| References |
| Molecular Formula | C21H27ClN4O7S2 |
|---|---|
| Molecular Weight | 547.04 |
| Storage condition | 2-8°C |