2136579-33-2
2136579-33-2 structure
- Name: AKR1B10-IN-1
- Chemical Name: AKR1B10-IN-1
- CAS Number: 2136579-33-2
- Molecular Formula: C19H16FNO4
- Molecular Weight: 341.33
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
- Create Date: 2022-02-20 15:06:19
- Modify Date: 2025-08-25 16:02:24
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AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1].
| Name | AKR1B10-IN-1 |
|---|---|
| Synonyms | N-(3-(4-Fluorophenyl)propyl) -7-hydroxycoumarin-3-carboxamide |
| Description | AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1]. |
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| Related Catalog | |
| Target |
3.5 nM (AKR1B10); 277 nM (AKR1B1)[1] |
| In Vitro | AKR1B10-IN-1 (compound 4e) (0-20 μM; 96 hours) dose-dependently suppresses the growth of both A549 and A549/1B10 cells[1]. AKR1B10-IN-1 (compound 4e) (0-20 μM; 96 hours) completely suppresses increased cell proliferation by the overexpressing AKR1B10 as well as the endogenous protein[1]. AKR1B10-IN-1 (compound 4e) (0-40 μM; 26 hours; pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours) decreases the cell viability of CDDP-R-A549 cells in a dose-dependent manner[1]. Cell Viability Assay[1] Cell Line: A549 cells, A549/1B10 cells (AKR1B10-stably overexpressing A549 cells) Concentration: 0, 10, 20 μM Incubation Time: 96 hours Result: Dose-dependently suppressed the growth of both A549 and A549/1B10 cells, and statistically significant at 20 μM. Cell Viability Assay[1] Cell Line: CDDP-resistance (cisplatin-resisitance) of A549 cells Concentration: 0, 10, 20, 40 μM Incubation Time: Pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours Result: Decreased the cell viability of CDDP-R-A549 cells in a dose-dependent manner, and most obvious in the treatment of 40 μM. |
| References |
| Molecular Formula | C19H16FNO4 |
|---|---|
| Molecular Weight | 341.33 |