2227482-41-7
2227482-41-7 structure
- Name: ELOVL1-IN-1
- Chemical Name: ELOVL1-IN-1
- CAS Number: 2227482-41-7
- Molecular Formula: C18H14F2N4O
- Molecular Weight: 340.33
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-03-08 18:13:05
- Modify Date: 2024-01-11 16:16:57
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ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1].
| Name | ELOVL1-IN-1 |
|---|
| Description | ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1]. |
|---|---|
| Related Catalog | |
| Target |
ELOVL1[1] |
| In Vitro | ELOVL1-IN-1 (compound 87) (1 nM-10 μM; 48 h) reduces the the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1]. |
| In Vivo | ELOVL1-IN-1 (compound 87) reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout (KO) mice (0.5-64 mg/kg; p.o. once daily for 28 days), wild‐type (WT) rats (30-300 mg/kg; p.o. once daily for 7 days), and cynomolgous monkeys (30 mg/kg; p.o. once daily for 7 days)[1]. |
| References |
| Molecular Formula | C18H14F2N4O |
|---|---|
| Molecular Weight | 340.33 |