882268-69-1

882268-69-1 structure

Name: HIF-2α-IN-4
Chemical Name: HIF-2α-IN-4
CAS Number: 882268-69-1
Molecular Formula: C₉H₉N₃O₄S₂
Molecular Weight: 287.32
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2022-03-09 19:00:19
Modify Date: 2025-08-25 12:00:23
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].

Name	HIF-2α-IN-4

Description	HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 5 μM (HIF-2α)[1]
In Vitro	HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1]. HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
References	[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.

Molecular Formula	C₉H₉N₃O₄S₂
Molecular Weight	287.32