342795-11-3
342795-11-3 structure
- Name: Namoline
- Chemical Name: Namoline
- CAS Number: 342795-11-3
- Molecular Formula: C10H3ClF3NO4
- Molecular Weight: 293.58
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2022-02-21 13:41:51
- Modify Date: 2024-01-06 15:11:23
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Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1].
| Name | Namoline |
|---|
| Description | Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1]. |
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| Related Catalog | |
| In Vitro | Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells[1]. Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells[1]. Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions[1]. |
| In Vivo | Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells[1]. |
| References |
| Molecular Formula | C10H3ClF3NO4 |
|---|---|
| Molecular Weight | 293.58 |