1269826-44-9
1269826-44-9 structure
- Name: OSBPL7-IN-1
- Chemical Name: OSBPL7-IN-1
- CAS Number: 1269826-44-9
- Molecular Formula: C20H19Cl2F3N2O3
- Molecular Weight: 463.28
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-03-14 19:10:26
- Modify Date: 2024-01-05 12:19:40
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OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
| Name | OSBPL7-IN-1 |
|---|
| Description | OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. |
|---|---|
| Related Catalog | |
| Target |
OSBPL7[1] ABCA1[1] |
| In Vitro | OSBPL7-IN-1 (compound G or Cpd G; 1-10 µM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. |
| In Vivo | OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1]. Animal Model: Female Balb/c mice induced by Adriamycin (ADR)[1] Dosage: 100 mg/kg Administration: Oral gavage; daily; for 28 days Result: Normalized proteinuria, and significantly reduced renal fibrosis and renal functional decline. |
| References |
| Molecular Formula | C20H19Cl2F3N2O3 |
|---|---|
| Molecular Weight | 463.28 |