116049-78-6

116049-78-6 structure

Name: SB-206606
Chemical Name: SB-206606
CAS Number: 116049-78-6
Molecular Formula: C₁₉H₂₂ClNO₄
Molecular Weight: 363.84
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2022-03-18 19:03:44
Modify Date: 2024-01-09 19:26:51
SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors[1].

Name	SB-206606

Description	SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	Beta-3 adrenergic receptor
In Vitro	[3H]SB-206606 binding to membranes from Chinese hamster ovary K1 cells transfected with the rat β3-AR with a Kd value of 58 nM[1]. [3H]SB-206606 binding to brown adipose tissue where beta 1-, beta 2-, and beta 3-adrenergic receptor subtypes are known to coexist with a Kd value of 38 nM[1].
References	[1]. Muzzin P, et al. Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606. Mol Pharmacol. 1994 Aug;46(2):357-63. PMID: 8078497.

Molecular Formula	C₁₉H₂₂ClNO₄
Molecular Weight	363.84