142057-80-5

142057-80-5 structure

Name: (S)-Donepezil
Chemical Name: (-)-Donepezil
CAS Number: 142057-80-5
Molecular Formula: C₂₄H₂₉NO₃
Molecular Weight: 379.49
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-05-16 21:16:58
Modify Date: 2025-08-26 00:43:38
(S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor[1][2].

Name	(-)-Donepezil
Synonyms	(2S)-2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone (2S)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one donepezil (S)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-Inden-1-one (S)-donepezil 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, (2S)-

Description	(S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Lili W, et al. Steady-state plasma concentration of donepezil enantiomers and its stereoselective metabolism and transport in vitro. Chirality. 2013 Sep;25(9):498-505. [2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.