1809296-92-1

1809296-92-1 structure

Name: TC AC 28
Chemical Name: TC AC 28
CAS Number: 1809296-92-1
Molecular Formula: C₂₃H₂₁N₅O₃
Molecular Weight: 415.44
Create Date: 2022-03-28 12:55:31
Modify Date: 2025-08-27 18:19:43
TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2(2), Brd2(1), respectively[1].

Name	TC AC 28
Synonyms	Methyl [6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid, 6-(1H-indol-4-yl)-8-methoxy-1-methyl-, methyl ester

Description	TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2(2), Brd2(1), respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD2(1):40 nM (Kd) BRD2(2):800 nM (EC50)
References	[1]. Khan R, et al. Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand. ACS Omega. 2017 Aug 8;2(8):4328-4332.