188174-64-3

188174-64-3 structure

Name: Palmitoyl coenzyme A lithium
Chemical Name: Palmitoyl coenzyme A lithium salt
CAS Number: 188174-64-3
Molecular Formula: C₃₇H₆₅LiN₇O₁₇P₃S
Molecular Weight: 1011.876
Catalog: Research Areas Metabolic Disease
Create Date: 2022-04-01 14:16:31
Modify Date: 2024-01-05 18:48:07
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis[1][2].

Name	Palmitoyl coenzyme A lithium salt
Synonyms	Palmitoyl coenzyme A lithium salt Palmitoyl coenzyme A lithium salt is also known as n-Hexadecanoyl Coenzyme A. n-Hexadecanoyl Coenzyme A Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxohexadecyl)thio]ethyl]amino]propyl]amino]butoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate), lithium salt (1:1) Hexadecanoyl coenzyme A MFCD01863103

Description	Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Palmitoyl coenzyme A lithium (100 μM) reversibly inhibits acetyl coenzyme A carboxylase activity from chicken hepatocytes and is competitive with citric acid and has an important role in the regulation of fatty acid synthesis in vivo[1]. Palmitoyl coenzyme A lithium with a high levels in mitochondria reduces the entry of ADP, which leads to an increased inhibition of glutamate dehydrogenase by palmitoyl CoA[2].
References	[1]. A G Goodridge, et al. Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem. 1972 Nov 10;247(21):6946-52. [2]. L A Fahien, et al. Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A. Arch Biochem Biophys. 1981 Nov;212(1):247-53.

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