2226517-75-3

2226517-75-3 structure

Name: Dynapyrazole-A
Chemical Name: Dynapyrazole A
CAS Number: 2226517-75-3
Molecular Formula: C₂₀H₁₂ClIN₄O
Molecular Weight: 486.7
Catalog: Signaling Pathways Cytoskeleton Dynamin
Create Date: 2022-03-20 13:38:11
Modify Date: 2024-02-15 12:08:50
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity[1].

Name	Dynapyrazole A
Synonyms	2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile 2-[1-(4-Chlorophenyl)cyclopropyl]-7-iodo-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carbonitrile 2-[1-(4-Chloro-phenyl)-cyclopropyl]-7-iodo-5-oxo-4,5-dihydro-pyrazolo[1,5-a]quinazoline-3-carbonitrile Pyrazolo[1,5-a]quinazoline-3-carbonitrile, 2-[1-(4-chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxo- Dynapyrazole-A

Description	Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cytoskeleton >> Dynamin
In Vitro	Dynapyrazole A (1- 3 μg/mL, 14 h) 在感染了 RVA-NMTL 病毒的 MA-104 细胞中，可以以剂量依赖的方式降低病毒滴度，EC 50 值为 0.73 μg/mL[1]。
References	[1]. Zhaoyang Jing, et al. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain. J Virol. 2021 Oct 13;95(21):e0124621.