2446474-05-9

2446474-05-9 structure

Name: Pomalidomide-C7-NH2 hydrochloride
Chemical Name: Pomalidomide 4'-alkylC7-amine
CAS Number: 2446474-05-9
Molecular Formula: C₂₀H₂₇ClN₄O₄
Molecular Weight: 422.91
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2022-03-20 19:55:06
Modify Date: 2024-04-03 18:06:53
Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC[1][2].

Name	Pomalidomide 4'-alkylC7-amine
Synonyms	1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) 4-[(7-Aminoheptyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride 4-[(7-Aminoheptyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)

Description	Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
References	[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [2]. Si Woo Choi, et al. Hmg-coa reductase degradation inducing compound. Patent, WO2021201577A1.