1418112-77-2
1418112-77-2 structure
- Name: AZD4721
- Chemical Name: AZD4721
- CAS Number: 1418112-77-2
- Molecular Formula: C19H25FN4O5S2
- Molecular Weight: 472.55
- Catalog: Signaling Pathways GPCR/G Protein CXCR
- Create Date: 2022-03-23 16:18:12
- Modify Date: 2024-01-10 13:33:52
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AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1].
| Name | AZD4721 |
|---|
| Description | AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1]. |
|---|---|
| Related Catalog | |
| Target |
CXCR2[1] |
| In Vivo | Assessment of Pharmacokinetics (PK) profile of AZD4721 (RIST4721) in rat and dog[1] . In Vivo PK Rat Dog Predicted hepatic metabolic CL (ml/min per kilogram) 1.7 0.80 Observed CL (ml/min per kilogram) 2.4 0.50 CLrenal (mL/min per kilogram) <0.01 <0.01 CLbiliary (mL/min per kilogram) <0.01 0.04 In vivo/in vitro unbound CLintc 1.4 0.6 VSS (l/kg) 0.19 0.15 T1/2 (h) (PO) 1.3 3.7 (2.7) (8.4) F (%) 45 82 |
| References |
| Molecular Formula | C19H25FN4O5S2 |
|---|---|
| Molecular Weight | 472.55 |