1854943-32-0

1854943-32-0 structure

Name: Iruplinalkib
Chemical Name: Iruplinalkib
CAS Number: 1854943-32-0
Molecular Formula: C₂₉H₃₈ClN₆O₂P
Molecular Weight: 569.08
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2022-03-24 23:09:29
Modify Date: 2024-01-12 07:57:31
Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement[1].

Name	Iruplinalkib

Description	Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	ALK and ROS1[1]
References	[1]. Shi Y, et al. Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial. Signal Transduct Target Ther. 2022;7(1):25.

Molecular Formula	C₂₉H₃₈ClN₆O₂P
Molecular Weight	569.08