Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AAK1-IN-3
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: AAK1-IN-3
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1802703-20-3

1802703-20-3 structure

1802703-20-3 structure

Name: AAK1-IN-3
Chemical Name: AAK1-IN-3
CAS Number: 1802703-20-3
Molecular Formula: C₂₀H₂₀N₄
Molecular Weight: 316.40
Catalog: Research Areas Neurological Disease
Create Date: 2022-05-25 11:28:52
Modify Date: 2024-01-08 02:17:42
AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].

Name	AAK1-IN-3

Description	AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3[1]. AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM)[1].
In Vivo	AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice[1].
References	[1]. Richard A Hartz, et al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155.

Molecular Formula	C₂₀H₂₀N₄
Molecular Weight	316.40