2135514-20-2

2135514-20-2 structure

Name: APJ receptor agonist 5
Chemical Name: APJ receptor agonist 5
CAS Number: 2135514-20-2
Molecular Formula: C₂₆H₂₉N₃O₆
Molecular Weight: 479.52
Catalog: Research Areas Cardiovascular Disease
Create Date: 2022-05-06 11:19:06
Modify Date: 2024-01-12 21:44:11
APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].

Name	APJ receptor agonist 5

Description	APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113.

Molecular Formula	C₂₆H₂₉N₃O₆
Molecular Weight	479.52