2648206-31-7
2648206-31-7 structure
- Name: EGFR-IN-21
- Chemical Name: EGFR-IN-21
- CAS Number: 2648206-31-7
- Molecular Formula: C36H44BrN10O2P
- Molecular Weight: 759.68
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2022-04-26 18:34:25
- Modify Date: 2024-01-11 19:33:47
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EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1].
| Name | EGFR-IN-21 |
|---|
| Description | EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFR:0.38 nM (IC50) |
| In Vitro | EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1]. |
| In Vivo | EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse[1]. EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1]. |
| References |
[1]. Lei Liu, et al. Polyaryl compounds as EGFR kinase inhibitors. WO2021104441. |
| Molecular Formula | C36H44BrN10O2P |
|---|---|
| Molecular Weight | 759.68 |