EGFR-IN-21

Modify Date: 2024-01-11 19:33:47

EGFR-IN-21 structure	Common Name	EGFR-IN-21
	CAS Number	2648206-31-7	Molecular Weight	759.68
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₄₄BrN₁₀O₂P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EGFR-IN-21

EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1].

Name	EGFR-IN-21

Description	EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.38 nM (IC50)
In Vitro	EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1].
In Vivo	EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse[1]. EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1].
References	[1]. Lei Liu, et al. Polyaryl compounds as EGFR kinase inhibitors. WO2021104441.

Molecular Formula	C₃₆H₄₄BrN₁₀O₂P
Molecular Weight	759.68

DC Chemicals Limited
China
Product Name: EGFR-IN-21
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

EGFR-IN-21 suppliers

EGFR-IN-21 price