EGFR-IN-21
Modify Date: 2025-08-22 18:17:18
EGFR-IN-21 structure
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Common Name | EGFR-IN-21 | ||
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| CAS Number | 2648206-31-7 | Molecular Weight | 759.68 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H44BrN10O2P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EGFR-IN-21EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1]. |
| Name | EGFR-IN-21 |
|---|
| Description | EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1]. |
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| Related Catalog | |
| Target |
EGFR:0.38 nM (IC50) |
| In Vitro | EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1]. |
| In Vivo | EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse[1]. EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1]. |
| References |
[1]. Lei Liu, et al. Polyaryl compounds as EGFR kinase inhibitors. WO2021104441. |
| Molecular Formula | C36H44BrN10O2P |
|---|---|
| Molecular Weight | 759.68 |
| InChIKey | LSEIPGIXLLFPNX-UHFFFAOYSA-N |
| SMILES | COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(-c2cnn(C)c2)cc1Nc1ncc(Br)c(Nc2cnc3ccccc3c2P(C)(C)=O)n1 |