802915-53-3
802915-53-3 structure
- Name: Fusarochromanone
- Chemical Name: Fusarochromanone
- CAS Number: 802915-53-3
- Molecular Formula: C15H20N2O4
- Molecular Weight: 292.33
- Catalog: Research Areas Cancer
- Create Date: 2022-04-24 17:14:48
- Modify Date: 2025-08-20 08:08:01
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Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity[1]. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS)[2].
| Name | Fusarochromanone |
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| Description | Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity[1]. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS)[2]. |
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| Related Catalog | |
| In Vitro | Fusarochromanone (FC101; 10 μM; 24 hours) induces apoptosis and an increase in proportion of cells in the sub-G1 phase in both HaCat and P9-WT cell lines[1]. Fusarochromanone (FC101; 0-1 μM; 24 h) induces the cleavage of both caspase-3 and PARP, a well-known substrate for activated caspases. FC101 does not affect the expression of the anti-apoptotic proteins, Bcl-2, Bcl-XL, Mcl-1, or the pro-apoptotic proteins BAD, BAK, BAX[1]. Fusarochromanone (FC101) exhibits very potent in-vitro growth inhibitory effects (IC50 ranging from 10 nM-2.5 μM) against HaCat (pre-malignant skin), P9-WT (malignant skin), MCF-7 (low malignant breast), MDA-231 (malignant breast), SV-HUC (premalignant bladder), UM-UC14 (malignant bladder), and PC3 (malignant prostate) in a time-course and dose-dependent manner, with the UM-UC14 cells being the most sensitive. Cell Cycle Analysis[1] Cell Line: HaCat and P9-WT cell lines Concentration: 10 μM Incubation Time: 24 hours Result: Showed cells in the G2 and M phases of the cell cycle for both cell lines. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 0.05 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM Incubation Time: 24 hours Result: Induced the cleavage of both caspase-3 and PARP. |
| In Vivo | Fusarochromanone (8 mg/kg; IP; 5 days per week; for 3.5 weeks) Is well tolerated, non-toxic, and achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day[1]. Animal Model: SCID Beige mice (CB17/Icr.Cg-PrkdcscidLystbg/Crl) injected with SRB12-p9 cells[1] Dosage: 8 mg/kg Administration: IP; 5 days per week; for 3.5 weeks Result: Achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day. |
| References |
| Molecular Formula | C15H20N2O4 |
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| Molecular Weight | 292.33 |