Shanghai Nianxing Industrial Co., Ltd
China
Product Name: OARV-771
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: OARV-771
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2683008-37-7

2683008-37-7 structure

2683008-37-7 structure

Name: OARV-771
Chemical Name: OARV-771
CAS Number: 2683008-37-7
Molecular Formula: C₄₉H₅₉ClN₈O₈S₂
Molecular Weight: 987.62
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-04-13 19:55:56
Modify Date: 2024-01-09 20:38:58
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively[1].

Name	OARV-771

Description	OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4:6 nM (DC50) BRD2:1 nM (DC50) BRD3:4 nM (DC50) VHL
In Vitro	OARV-771 shows antiproliferative effect with an EC50 value of 4 nM in MV4;11[1].
References	[1]. Klein VG, et al. Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. J Med Chem. 2021;64(24):18082-18101.

Molecular Formula	C₄₉H₅₉ClN₈O₈S₂
Molecular Weight	987.62

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