Shanghai Nianxing Industrial Co., Ltd
China
Product Name: OM-153
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: OM-153
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2406278-81-5

2406278-81-5 structure

2406278-81-5 structure

Name: OM-153
Chemical Name: OM-153
CAS Number: 2406278-81-5
Molecular Formula: C₂₈H₂₄FN₇O₂
Molecular Weight: 509.53
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2022-04-06 17:17:16
Modify Date: 2024-01-10 17:09:39
OM-153 is a potent tankyrase inhibitor with IC50s of 13 and 2 nM for tankyrase 1 and tankyrase 2, respectively. OM-153 shows inhibition of WNT/β-catenin signaling and proliferation in COLO 320DM[1].

Name	OM-153

Description	OM-153 is a potent tankyrase inhibitor with IC50s of 13 and 2 nM for tankyrase 1 and tankyrase 2, respectively. OM-153 shows inhibition of WNT/β-catenin signaling and proliferation in COLO 320DM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	TNKS1:13 nM (IC50) TNKS2:2 nM (IC50)
In Vitro	OM-153 shows picomolar IC50 inhibition (0.63 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay, no off-target liabilities, overall favorable absorption, distribution, metabolism, and excretion (ADME) properties, and an improved pharmacokinetic profile in mice[1].
References	[1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949.

Molecular Formula	C₂₈H₂₄FN₇O₂
Molecular Weight	509.53